Key result
Plasma TIMP-1 was significantly elevated in never-treated hypertensive patients compared to normal subjects (358 vs 253 ng/mL, P<0.001) and predicted left ventricular diastolic dysfunction.
Why the study?
Do plasma markers of collagen turnover (TIMP-1, PICP, CITP) correlate with echocardiographic evidence of diastolic dysfunction in untreated hypertensive patients?
Population
100 never-treated hypertensive patients and 50 normal subjects
Comparison
Measurement of plasma markers of collagen… vs Normal subjects and patients without diastolic…
Design
Cross-sectional
Authors
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Should not yet change hypertension practice; hypothesis-generating for TIMP-1 as fibrosis marker in diastolic dysfunction.
Observational (n=150)
Do plasma markers of collagen turnover (TIMP-1, PICP, CITP) correlate with echocardiographic evidence of diastolic dysfunction in untreated hypertensive patients?
Absolute Event Rate: 358% vs 253%
p-value: p=<0.001
Plasma TIMP-1 is elevated in untreated hypertension and correlates with echocardiographic markers of diastolic dysfunction, suggesting its potential as a noninvasive marker of myocardial fibrosis.
Lindsay et al. (2002) conducted an observational in Hypertension (n=150). Plasma TIMP-1 vs. Normal subjects was evaluated on Plasma TIMP-1 levels (p=<0.001). Plasma TIMP-1 was significantly elevated in never-treated hypertensive patients compared to normal subjects (358 vs 253 ng/mL, P<0.001) and predicted left ventricular diastolic dysfunction.