Why the study?
What are the hemodynamic effects of quantitatively varied experimental mitral regurgitation in open-chest dogs?
What are the hemodynamic effects of quantitatively varied experimental mitral regurgitation in open-chest dogs?
An experimental open-chest dog model demonstrated that 2 L/min of mitral regurgitant flow produces minimal acute hemodynamic compromise.
Acute animal model data leave open hemodynamic tolerance of moderate MR in humans; human studies needed before clinical inference.
Mitral regurgitation was produced in the open-chest dog by permitting blood to flow from left ventricle through a flow meter into the left atrium during systole. The hemodynamic effects of known amounts of regurgitation were studied. Two liters per minute of mitral regurgitant flow had relatively little effect on effective cardiac output, aortic pressure, left atrial pressure and on the left ventricular function curve.
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Braunwald et al. (1957) studied this question.
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