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This perspective article examines the integration of traditional phytotherapy into precision medicine for cardiovascular remodeling associated with cardiometabolic syndrome (CMS). Herbal medicine, with its intrinsic multi-target action, aligns well with the complex network pathology of CMS. However, challenges remain in standardizing its use and elucidating its mechanisms. We argue that multi-omics biomarkers—spanning genomics, transcriptomics, proteomics, metabolomics, and microbiomics—are essential for systematically deciphering the systemic effects of herbal interventions. By identifying specific biomarker profiles that predict efficacy, stratify patients, and monitor treatment response, traditional herbal therapy can evolve from a holistic practice into an evidence-based, personalized approach. This strategy offers a rigorous, scientifically grounded pathway to individualized cardiovascular remodeling management, effectively bridging empirical wisdom with contemporary precision medicine.
Yu et al. (Wed,) studied this question.