Increased extracellular sodium and calcium significantly attenuated conduction slowing during no-flow ischemia, an effect associated with selective widening of the perinexus.
Does increased extracellular sodium and calcium attenuate conduction slowing during no-flow ischemia?
Increasing extracellular sodium and calcium attenuates conduction slowing during acute ischemia by modulating ephaptic coupling via perinexus widening.
Conduction slowing during acute ischemia creates an arrhythmogenic substrate. We have shown that extracellular ionic concentrations can alter conduction by modulating ephaptic coupling. Here, we demonstrate increased extracellular sodium and calcium significantly attenuate conduction slowing during no-flow ischemia. This effect was associated with selective widening of the perinexus, an intercalated disc nanodomain and putative cardiac ephapse. These findings suggest that acute changes in ephaptic coupling may serve as an adaptive response to ischemic stress.
Hoeker et al. (Fri,) conducted a other in Acute ischemia. Increased extracellular sodium and calcium was evaluated on Conduction slowing during no-flow ischemia. Increased extracellular sodium and calcium significantly attenuated conduction slowing during no-flow ischemia, an effect associated with selective widening of the perinexus.