Characterization of Vascular Disease Risk in Postmenopausal Women and Its Association with Cognitive Performance
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Implication
Randomized trial examines vascular disease risk profiles and cognitive performance in postmenopausal women, suggesting educational impacts on risk classification.
Key Points
- This study aims to explore the heterogeneity in vascular disease risk among postmenopausal women and its link to cognitive performance.
- 727 recently postmenopausal women participated, cognitively healthy and free of cardiovascular disease.
- Latent profile analysis was applied to categorize cardiovascular risk profiles based on demographic and genetic predictors.
- A supervised random forest algorithm with 10-fold cross-validation was utilized to test the accuracy of risk classification.
- 62% of women were classified as 'low-risk' and 38% as 'high-risk'.
- Low-risk women outperformed high-risk women in language and mental flexibility tasks (p = 0.008) and overall cognition (p = 0.029).
- Higher education levels increased likelihood of being in the low-risk class (OR = 1.595, p = 0.044).
Cite This Study
Dowling et al. (2013) studied this question.