Admission serum sodium levels <135 mmol/L were associated with an increased risk of all-cause mortality in heart failure patients compared to levels of 139-141 mmol/L (HR 1.67; 95% CI 1.29-2.16).
Cohort (n=3,649)
No
Are hyponatremia and lower normal serum sodium levels on admission associated with an increased risk of all-cause mortality in patients hospitalized with heart failure?
Both hyponatremia and lower normal serum sodium levels on admission are associated with an increased risk of all-cause mortality in patients hospitalized with heart failure.
Estimación del efecto: HR 1.67 (95% CI 1.29-2.16)
AIM: To explore the relationship between the serum sodium level on admission and all-cause mortality in HF patients. DESIGN: A single-center retrospective cohort study. METHODS: Patients hospitalized with HF at the Heart Failure Center, Fuwai Hospital, from November 2008 to November 2018 were enrolled. RESULTS: A total of 3649 patients were included, and the mean sodium level was 137.19 ± 4.36 mmol/L, with a range from 115.6 to 160.9 mmol/L. During a median follow-up of 1101 days, mortality occurred in 1413 (38.7%) hospital survivors. After adjustment for age, sex, and other potential confounders, patients with sodium levels <135 mmol/L (hazard ratio HR: 1.67; 95% confidence interval CI: 1.29-2.16) and 135-137 mmol/L (HR: 1.34; 95% CI: 1.01-1.78) had an increased risk of all-cause mortality compared to those with sodium levels of 139-141 mmol/L.
Zhao et al. (Thu,) conducted a cohort in Heart failure (n=3,649). Serum sodium level <135 mmol/L vs. Serum sodium level 139-141 mmol/L was evaluated on All-cause mortality (HR 1.67, 95% CI 1.29-2.16). Admission serum sodium levels <135 mmol/L were associated with an increased risk of all-cause mortality in heart failure patients compared to levels of 139-141 mmol/L (HR 1.67; 95% CI 1.29-2.16).