Effects of Rivaroxaban on Biomarkers of Coagulation and Inflammation: A Post Hoc Analysis of the X-VeRT Trial

Fig. 1. Patient flow and overview of biomarker collection. EoT, end of treatment; hs-CRP, high-sensitivity C-reactive protein; mITT, modified intention-to-treat; OAC, oral anticoagulant. a Patients in the mITT population in whom a left atrial thrombus was not diagnosed during transesophageal echocardiography performed before the first planned cardioversion. b Reasons for missing results, for example, specimen not frozen, insufficient quantity, hemolysis. c Availability of samples based on available hs-CRP measurements; end of treatment samples could still be collected from patients without a baseline sample.

Fig. 2. Influence of pretreatment with OACs on F1.2 levels at baseline. F1.2, prothrombin fragment 1 + 2; OAC, oral anticoagulant; ULOQ, upper limit of quantification. Note: Upper lines of the box denote the upper quartiles, midlines denote the medians and lower lines denote the lower quartiles; crosses denote the geometric means, and upper and lower lines denote maximum and minimum values, excluding outliers (i.e., values that are >1.5 times the interquartile range further apart from the box).

Fig. 3. Influence of a history of congestive HF on hs-CRP levels at baseline. HF, heart failure; hs-CRP, high-sensitivity C-reactive protein; LLOQ, lower limit of quantification; OAC, oral anticoagulant. Note: Upper lines of the box denote the upper quartiles, midlines denote the medians and lower lines denote the lower quartiles; crosses denote the geometric means, and upper and lower lines denote maximum and minimum values, excluding outliers (i.e., values that are >1.5 times the interquartile range further apart from the box).

Fig. 4. Influence of type of AF on levels of D-dimer at baseline. AF, atrial fibrillation; FEU, fibrinogen equivalent units; LLOQ, lower limit of quantification; OAC, oral anticoagulant. Note: Upper lines of the box denote the upper quartiles, mid-lines denote the medians and lower lines denote the lower quartiles; crosses denote the geometric means, and upper and lower lines denote maximum and minimum values, excluding outliers (i.e., values that are >1.5 times the interquartile range further apart from the box).

Fig. 5. Relative changes of biomarker levels from baseline to the end of treatment, model-adjusted for biomarker baseline level, and treatment duration. F1.2, prothrombin fragment 1 + 2; hs-CRP, high-sensitivity C-reactive protein; hs-IL-6, high-sensitivity interleukin-6; TAT, thrombin–anti-thrombin III complex; VKA, vitamin-K antagonist. Note: Upper lines of the box denote the upper quartiles, mid-lines denote the medians and lower lines denote the lower quartiles; crosses denote the geometric means, and upper and lower lines denote maximum and minimum values, excluding outliers (i.e., values that are >1.5 times the interquartile range further apart from the box).