What is the clinical evidence from this study?

Study design: Observational. Population: Patients with and without a documented history of ventricular tachycardia (n=17). Intervention: Intracardiac recordings (ICR). Primary outcome: Presence of fragmented ventricular electrograms (VE).

What does this research mean for the field?

Fragmented ventricular electrograms were recorded in the left ventricle of 100% and the right ventricle of 23.5% of patients, regardless of ventricular tachycardia history, and may represent artifacts rather than a necessary mechanism for reentrant ventricular tachycardia. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

This research aims to explore the relationship between fragmented ventricular electrograms and occurrences of ventricular tachycardia in patients with heart disease.

December 1, 1980CirculationOpen Access

Significance of fragmented ventricular electrograms observed using intracardiac recording techniques in man.

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Key result

Fragmented ventricular electrograms were recorded in the left ventricle of 100% and the right ventricle of 23.5% of patients, regardless of ventricular tachycardia history, and may represent artifacts.

Why the study?

Does the presence of fragmented ventricular electrograms on intracardiac recordings correlate with the mechanism of ventricular tachycardia in humans?

Key Points

This research aims to explore the relationship between fragmented ventricular electrograms and occurrences of ventricular tachycardia in patients with heart disease.
Studied 17 patients using intracardiac recordings, with varying histories of ventricular tachycardia.
Recorded left and right ventricular electrograms at multiple sites with different interelectrode distances and filter settings.
Analyzed the relationship of electrogram fragmentation with induced ventricular tachycardia.
Fragmented ventricular electrograms recorded in 100% of patients and in 23.5% of patients with right ventricular recordings.
Atrial pacing induced VE fragmentation without corresponding VT induction.
VT episodes were not related to VE fragmentation, and interrupting fragmentation did not stop VT.

Study Design

Type

Observational (n=17)

Structured PICO

Does the presence of fragmented ventricular electrograms on intracardiac recordings correlate with the mechanism of ventricular tachycardia in humans?

Population

17 patients, 5 with and 12 without a documented history of ventricular tachycardia (VT). Underlying conditions included cardiomyopathy (n=2), arteriosclerotic heart disease (n=5, 3 with ventricular aneurysm), rheumatic heart disease (n=5), congenital heart disease (n=2), and no apparent heart disease (n=3).

Intervention

Intracardiac recordings (ICR) of left and right ventricular electrograms (VE) at multiple sites with variable interelectrode distances and filter frequency settings.

Outcome

Detection of fragmented ventricular electrograms and its relationship to ventricular tachycardia.surrogate

Fragmented ventricular electrograms can be observed in patients with and without ventricular tachycardia, are highly dependent on recording techniques, and may represent artifacts rather than solely reflecting arrhythmogenic substrate.

Limitations

Fragmentation of the VE may represent artifacts associated with intracardiac catheter electrode movement during cardiac systole and diastole.

Discussion

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Implication

Challenges interpretation of fragmented electrograms as VT substrate markers; leaves open their mechanistic role pending controlled validation.

Cite This Study

Waxman et al. (1980) conducted an observational in Patients with and without a documented history of ventricular tachycardia (n=17). Intracardiac recordings (ICR) was evaluated on Presence of fragmented ventricular electrograms (VE). Fragmented ventricular electrograms were recorded in the left ventricle of 100% and the right ventricle of 23.5% of patients, regardless of ventricular tachycardia history, and may represent artifacts.

synapsesocial.com/papers/6a155bb137103a43379f9cda https://doi.org/10.1161/01.cir.62.6.1349

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Implication

Challenges interpretation of fragmented electrograms as VT substrate markers; leaves open their mechanistic role pending controlled validation.

Significance of fragmented ventricular electrograms observed using intracardiac recording techniques in man.

Key Points

Study Design

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Significance of fragmented ventricular electrograms observed using intracardiac recording techniques in man.

Key Points

Study Design

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider