Key result
Dobutamine infusion linked to higher LV s' and e' velocities via excursion and duration changes.
Why the study?
Dobutamine effects on the relationships between left ventricular long-axis excursion, timing, and peak systolic (s') and early diastolic (e') tissue Doppler velocities were unknown.
Does dobutamine affect systolic and diastolic left ventricular long-axis excursion and timing as measured by tissue Doppler imaging?
Observational (n=10)
Does dobutamine affect systolic and diastolic left ventricular long-axis excursion and timing as measured by tissue Doppler imaging?
Dobutamine increases systolic and early diastolic peak velocities (s' and e') via changes in excursion and systolic duration, but the lack of effect on diastolic times does not support a lusitropic effect.
Dobutamine effects on TDI velocities warrant caution in clinical interpretation; leaves open whether it exerts true lusitropic action.
BACKGROUND: Dobutamine effects on the relationships of the peak velocity of left ventricular (LV) long-axis systolic motion (s') with systolic excursion (SExc), systolic duration (SDur) and heart rate, of LV long-axis early diastolic excursion (EDExc) with SExc, and of the peak velocity of LV long-axis early diastolic motion (e') with EDExc, early diastolic duration (EDDur) and isovolumic relaxation time (IVRT') are unknown. METHODS: = 10), were studied, with the aim of identifying consistent findings for the two groups and for the septal and lateral walls. Dobutamine was infused at doses of 5 and 10 µg/kg/min. The relationships between tissue Doppler imaging (TDI) variables acquired before and during dobutamine infusion were analysed using mixed effect multivariate regression modelling. RESULTS: In both groups, heart rate increased and SDur decreased during dobutamine infusion, and there were independent inverse correlations of SDur with heart rate and dobutamine dose. In contrast, there was no change in EDDur during dobutamine infusion, and no consistent changes in IVRT' independent of heart rate. s' was positively correlated with SExc and inversely correlated with SDur, and there were positive correlations between EDExc and SExc and between e' and EDExc. CONCLUSION: Dobutamine increases s' due to effects on both systolic excursion and duration and it increases e' due to the associated increases in systolic and early diastolic excursion. A lack of effect on diastolic times does not support the presence of a lusitropic effect of dobutamine.
No takes yet. Share an insight, caveat, or question.
Peverill et al. (2023) reported an observational. Dobutamine vs. Before dobutamine infusion was evaluated on Relationships between tissue Doppler imaging variables (s', SExc, SDur, EDExc, e', EDDur, IVRT') and heart rate. Dobutamine infusion increases peak velocity of left ventricular long-axis systolic (s') and early diastolic (e') motion by affecting excursion and duration, without altering diastolic times.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: