Key result
In Chinese men, heavy alcohol consumption of >60.0 g/d was associated with a significantly higher risk of peripheral artery disease (OR 2.878) compared to never drinking.
Why the study?
Does alcohol consumption affect the Ankle-to-Brachial Index and the risk of peripheral artery disease in Chinese adults?
Cross-Sectional (n=14,618)
Yes
Does alcohol consumption affect the Ankle-to-Brachial Index and the risk of peripheral artery disease in Chinese adults?
Effect estimate: OR 2.878 (95% CI 1.215-4.018)
Absolute Event Rate: 15.2% vs 4.44%
p-value: p=<0.001
In Chinese men, moderate alcohol consumption (<60 g/day) is inversely associated with peripheral atherosclerosis, whereas heavy consumption (≥60 g/day) significantly increases the risk of peripheral artery disease.
Heavy drinking may raise PAD risk in Chinese men; hypothesis-generating and needs prospective confirmation before practice change.
BACKGROUND AND METHODOLOGY: A low ankle-to-brachial index (ABI) is a strong correlate of cardiovascular disease and subsequent mortality. The relationship between ABI and alcohol consumption remains unclear. Data are from the Cardiovascular Risk Survey (CRS), a multiple-ethnic, community-based, cross-sectional study of 14,618 Chinese people (5757 Hans, 4767 Uygurs, and 4094 Kazakhs) aged 35 years and over at baseline from Oct. 2007 to March 2010. The relationship between alcohol intake and ABI was determined by use of analysis of covariance and multivariable regressions. PRINCIPAL FINDINGS: In men, alcohol consumption was significantly associated with ABI (P<0.001). After adjusted for the confounding factors, such as age, sex, ethnicity, body mass index, smoking, work stress, diabetes, and fasting blood glucose, the difference remained significant (P<0.001); either the unadjusted or multivariate-adjusted odds ratio (OR) for peripheral artery disease (PAD) was significantly higher in men who consumed >60.0 g/d [OR = 3.857, (95% CI: 2.555-5.824); OR = 2.797, (95% CI: 1.106-3.129); OR = 2.878, (95% CI: 1.215-4.018); respectively] and was significantly lower in men who consumed 20.1-40.0 g/d [OR= 0.330, (95% CI: 0.181-0.599); OR = 0.484, (95% CI: 0.065-0.894); OR = 0.478, (95% CI: 0.243-1.534); respectively] and 40.1-60.0 g/d [OR= 0.306, (95% CI: 0.096-0.969); OR = 0.267, (95% CI: 0.087-0.886); OR = 0.203, (95% CI: 0.113-0.754); respectively] compared with never drinking, respectively (all P<0.01). Neither in unadjusted nor in multivariate-adjusted model was the association between ABI and alcohol consumption significant (all P>0.05) in women. Similarly, PAD was not correlated with alcohol intake in women (all P>0.05). CONCLUSIONS/SIGNIFICANCE: Our results indicated that in Chinese men, alcohol consumption was associated with peripheral artery disease, and consumption of less than 60 g/d had an inverse association with peripheral atherosclerosis whereas consumption of 60 g/d or more had a positive association.
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Xie et al. (2010) conducted a cross-sectional in Peripheral artery disease (n=14,618). Alcohol consumption vs. Never drinking was evaluated on Peripheral artery disease (PAD) (OR 2.878, 95% CI 1.215-4.018, p=<0.001). In Chinese men, heavy alcohol consumption of >60.0 g/d was associated with a significantly higher risk of peripheral artery disease (OR 2.878) compared to never drinking.
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