Chronic myocardial and coronary arterial effects of intracoronary supersaturated oxygen therapy in swine with normal and ischemic-reperfused myocardium

Figures

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  Figure 1. Essentials of study design in form of a flow chart.

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  Figure 2. Side-by-side comparison of representative mid-basal left ventricular cross-sections from all 8 study subgroups. In the MI groups, areas of myocardial necrosis/scars, as defined by the study pathologist, are outlined by yellow lines.

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  Figure 3. Key myocardial morphometric indices at 7 days. No early differences in histomorphometric indices of myocardial infarction injury can be observed hearts subjected to the SSO2 therapy in comparison to sham.

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  Figure 4. Key myocardial morphometric indices at 30 days. Note the trend toward less prominent histomorphometric indices of myocardial infarction injury in the SSO2 therapy in comparison to sham.

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  Figure 5. Key semiquantitative metrics of arterial healing at 7 days (A) and at 30 days (B). Overall, there is no negative impact of SSO2 therapy on the arterial healing parameters in comparison to sham. The incidental statistically significant differences in injury and fibrin deposition are discussed in the text.

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  Figure 6. Representative in-stent coronary arterial cross-sections from all 8 study subgroups. Typical histological responses to stent placement in normal porcine arteries at 7 days (upper panels) and 30 days (lower) panels. No excess early thrombus formation at 7 days or excess neointima formation at 30 days are seen as a result of SSO2 therapy in comparison to sham. Note: Figs. 1, 2 and 6 generated with Microsoft Office 365 utilizing histology and histomorphometry images generated with ImagePro Plus (MediaCybernetics). Figs. 3, 4 and 5 generated with SigmaPlot v 11.0 (Build 11.2.0.5).