A full-size cDNA coding for human cardiac troponin T was isolated, detecting a 1.2 kb mRNA that increases during heart development and is transiently coexpressed in fetal skeletal muscle.
We have isolated a full-size cDNA coding for cardiac troponin T (cTnT) from a human adult heart library, using a slow skeletal TnT probe. This cDNA detected a 1.2 kb mRNA in fetal and post-natal human heart, the amount of which increased during ontogenic development. Interestingly, a similar transcript was coexpressed in fetal skeletal muscle, together with the 0.9 kb slow skeletal muscle mRNA, and its expression was down-regulated during further development.
Mesnard et al. (Mon,) reported a other. A full-size cDNA coding for human cardiac troponin T was isolated, detecting a 1.2 kb mRNA that increases during heart development and is transiently coexpressed in fetal skeletal muscle.