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A full-size cDNA coding for human cardiac troponin T was isolated, detecting a 1.2 kb mRNA that increases during heart development and is transiently coexpressed in fetal skeletal muscle.
This study successfully cloned human cardiac troponin T and demonstrated its developmental expression patterns in cardiac and skeletal muscle.
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Cloned cardiac troponin T cDNA enables developmental studies; leaves open clinical translation in cardiomyopathy.
We have isolated a full-size cDNA coding for cardiac troponin T (cTnT) from a human adult heart library, using a slow skeletal TnT probe. This cDNA detected a 1.2 kb mRNA in fetal and post-natal human heart, the amount of which increased during ontogenic development. Interestingly, a similar transcript was coexpressed in fetal skeletal muscle, together with the 0.9 kb slow skeletal muscle mRNA, and its expression was down-regulated during further development.
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Mesnard et al. (1993) studied this question. A full-size cDNA coding for human cardiac troponin T was isolated, detecting a 1.2 kb mRNA that increases during heart development and is transiently coexpressed in fetal skeletal muscle.
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