Key result
Serum calcium shows a U-shaped association with all-cause mortality in CHD patients with CKD.
Why the study?
Is serum calcium associated with all-cause mortality in patients with coronary heart disease and chronic kidney disease?
Cohort (n=3,564)
Yes
Is serum calcium associated with all-cause mortality in patients with coronary heart disease and chronic kidney disease?
Answers are grounded in this paper and cite their sources.
Serum calcium levels exhibit a U-shaped association with all-cause mortality in patients with concurrent coronary heart disease and chronic kidney disease.
BACKGROUND: Chronic kidney disease (CKD), as a major risk factor for coronary heart disease (CHD), had a large fluctuation of serum calcium in clinical research. Our study aims to identify the association between serum calcium and all-cause mortality in CHD patients with CKD. METHODS: A retrospective cohort study was conducted, involving 2,286 participants from the CHD sub-cohort from the Eastern Guangdong Health and Disease Cohort Platform (EGHDCP) and 1,278 participants from National Health and Nutrition Examination Survey (NHANES) database. Cox proportional hazards regression models, stratified analysis with interaction, restricted cubic splines (RCS), and threshold effect analysis were applied to investigate the association between serum calcium and all-cause mortality of CHD with CKD. CONCLUSION: There was an U-shaped connection between serum calcium and all-cause mortality in CHD patients with CKD.
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Su et al. (2025) conducted a cohort in Coronary heart disease with chronic kidney disease (n=3,564). Serum calcium was evaluated on All-cause mortality (p== 0.0302). Serum calcium demonstrated a U-shaped association with all-cause mortality in patients with coronary heart disease and chronic kidney disease (P=0.0302).
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