Key result
Pulmonary vein isolation using a circular decapolar catheter with duty-cycled unipolar/bipolar RF energy achieved freedom from AF off antiarrhythmic drugs in 79% of patients at 1-year follow-up.
Why the study?
Does pulmonary vein isolation using a circular mapping/ablation decapolar catheter with duty-cycled bipolar/unipolar RF energy improve freedom from AF in patients with symptomatic paroxysmal AF?
Cohort (n=88)
Does pulmonary vein isolation using a circular mapping/ablation decapolar catheter with duty-cycled bipolar/unipolar RF energy improve freedom from AF in patients with symptomatic paroxysmal AF?
Pulmonary vein isolation using a circular decapolar catheter with duty-cycled unipolar/bipolar RF energy is highly effective and safe for paroxysmal AF, with stable results at 12 months.
Answers are grounded in this paper and cite their sources.
Supports feasibility of this PVI approach in paroxysmal AF; leaves open comparative efficacy versus standard techniques in RCTs.
BACKGROUND: Electrical disconnection of the pulmonary veins (PV) plays an important role in the ablation of paroxysmal atrial fibrillation (AF). Antral ablation using a conventional steerable ablation catheter often is technically challenging and time consuming. METHODS: Eighty-eight patients (mean age 58 +/- 11 years) with symptomatic paroxysmal AF underwent ablation with a circular mapping/ablation decapolar catheter (PVAC). Ablation was performed in the antral region of the PVs with a power-modulated bipolar/unipolar radiofrequency (RF) generator using 8-10 W delivered simultaneously through 2-10 electrodes, as selected by the operator. Seven-day Holter monitor recordings were performed off antiarrhythmic drugs at 3-, 6-, and 12-month follow-up, and patients were requested to visit the hospital in the event of ongoing palpitations. All follow-up patients were divided into 2 groups: Group 1 with a follow-up of less than 1 year and group 2 patients completing a 1-year follow-up. RESULTS: Overall, 338 of 339 targeted PVs (99%) were isolated with the PVAC with a mean of 24 +/- 9 RF applications per patient, a mean total procedure time of 125 +/- 28 minutes, and a mean fluoroscopy time of 21 +/- 13 minutes. Freedom from AF off antiarrhythmic drugs was found in 82 and 79% of group 1 and group 2 patients, respectively. No procedure-related complications were observed. CONCLUSION: PV isolation by duty-cycled unipolar/bipolar RF ablation can be effectively and safely performed with a circular, decapolar catheter. Twelve-month follow-up data compare favorably with early postablation results, indicating stable effects over time.
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Wieczorek et al. (2009) conducted a cohort in Symptomatic paroxysmal atrial fibrillation (n=88). Duty-cycled bipolar and unipolar radiofrequency ablation via circular decapolar catheter (PVAC) was evaluated on Freedom from AF off antiarrhythmic drugs. Pulmonary vein isolation using a circular decapolar catheter with duty-cycled unipolar/bipolar RF energy achieved freedom from AF off antiarrhythmic drugs in 79% of patients at 1-year follow-up.
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