What question did this study set out to answer?

This research aims to investigate the effectiveness of parasympathetic nerve stimulation (PNS) at the inferior vena cava to manage rapid ventricular rates during atrial fibrillation.

January 1, 2000Journal of Cardiovascular Electrophysiology

Transvenous Parasympathetic Nerve Stimulation in the Inferior Vena Cava and Atrioventricular Conduction

Q: What is the clinical evidence from this study?

Population: Atrial fibrillation (n=10). Intervention: Transvenous parasympathetic nerve stimulation in the inferior vena cava vs. Without parasympathetic nerve stimulation. Primary outcome: Ventricular rate (RR interval in msec) during atrial fibrillation (p=0.005).

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Key result

Transvenous parasympathetic nerve stimulation in the inferior vena cava significantly slowed ventricular rate during atrial fibrillation in dogs (1,539 vs 266 msec; P=0.005).

Why the study?

Does transvenous parasympathetic nerve stimulation in the inferior vena cava reduce ventricular rate during atrial fibrillation in a dog model?

Key Points

This research aims to investigate the effectiveness of parasympathetic nerve stimulation (PNS) at the inferior vena cava to manage rapid ventricular rates during atrial fibrillation.
PNS was administered in ten canine subjects using a catheter with an electrode basket.
Stimuli were provided in rectangular pulses at 20 Hz for a duration of 0.1 msec.
Effects on ventricular rates and AV nodal electrophysiology were assessed during and after stimulation.
Without PNS, the average ventricular rate was 266 +/- 79 msec, while with PNS at 34 V it slowed to 1,539 +/- 2,460 msec (P = 0.005).
PNS induced dual AV nodal electrophysiology in all three dogs when assessed in sinus rhythm.
No significant changes in sinus rate or arterial blood pressure were noted during ventricular pacing.

Structured PICO

Does transvenous parasympathetic nerve stimulation in the inferior vena cava reduce ventricular rate during atrial fibrillation in a dog model?

Population

10 dogs with induced atrial fibrillation

Intervention

Parasympathetic nerve stimulation (PNS) in the inferior vena cava (IVC) using rectangular stimuli (0.1 msec/20 Hz) delivered through a catheter with an expandable electrode basket, with stepwise voltage increase from 2 to 34 V

Comparator

Baseline (without PNS)

Outcome

Ventricular rate slowing during atrial fibrillationsurrogate

Main Result

Absolute Event Rate: 1539% vs 266%

p-value: p=0.005

Transvenous parasympathetic nerve stimulation in the inferior vena cava effectively slows ventricular rate during atrial fibrillation in a canine model.

Discussion

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Implication

Hypothesis-generating for IVC PNS in AF rate control; leaves open translation to human use.

Cite This Study

Schauerte et al. (2000) studied Atrial fibrillation (n=10). Transvenous parasympathetic nerve stimulation in the inferior vena cava vs. Without parasympathetic nerve stimulation was evaluated on Ventricular rate (RR interval in msec) during atrial fibrillation (p=0.005). Transvenous parasympathetic nerve stimulation in the inferior vena cava significantly slowed ventricular rate during atrial fibrillation in dogs (1,539 vs 266 msec; P=0.005).

synapsesocial.com/papers/6a1563a45347fbb1739fb38c https://doi.org/10.1111/j.1540-8167.2000.tb00738.x

Topics

Atrial fibrillation Persistent AF management Anticoagulation in AF

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Transvenous Parasympathetic Nerve Stimulation in the Inferior Vena Cava and Atrioventricular Conduction

Key Points

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Topics

Transvenous Parasympathetic Nerve Stimulation in the Inferior Vena Cava and Atrioventricular Conduction

Key Points

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider