Key result
Central cannulation in fetal sheep causes substantially greater LV impairment than peripheral cannulation.
Why the study?
Fetal cardiac surgery for critical congenital heart diseases depends on reliable fetal cardiopulmonary bypass, which remains experimental, prompting exploration of differences between central and peripheral cannulation strategies.
Does central cannulation compared to peripheral cannulation affect cardiac function and organ perfusion in fetal sheep undergoing cardiopulmonary bypass?
Comparison
Central cannulation vs peripheral cannulation
Design
Randomized animal study
Follow-up
60 min after initiation of CPB
Authors
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Central cannulation may impair fetal LV function more than peripheral in this model; leaves optimal cannulation strategy open for human translation.
RCT (n=10)
Randomized
No
Does central cannulation compared to peripheral cannulation affect cardiac function and organ perfusion in fetal sheep undergoing cardiopulmonary bypass?
Absolute Event Rate: 1.96% vs 0.45%
p-value: p=0.028
In a fetal sheep model of cardiopulmonary bypass, central cannulation causes more adverse impacts on cardiac function, whereas peripheral cannulation is more susceptible to inadequate organ perfusion.
Teng et al. (2021) conducted an RCT in Fetal cardiopulmonary bypass (n=10). Central cannulation vs. Peripheral cannulation was evaluated on Left ventricular Tei index at 60 minutes (p=0.028). Central cannulation in fetal sheep caused greater impairment of left ventricular function compared to peripheral cannulation, evidenced by a significantly higher Tei index (1.96 vs 0.45) at 60 minutes.
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