Key result
In pediatric patients with dilated cardiomyopathy receiving conventional treatment, 41.4% recovered normal systolic function and 19.5% died, with initial ejection fraction not predicting outcomes.
Why the study?
What are the prognostic factors for death or recovery of systolic function in pediatric dilated cardiomyopathy patients receiving conventional treatment?
Observational (n=41)
No
What are the prognostic factors for death or recovery of systolic function in pediatric dilated cardiomyopathy patients receiving conventional treatment?
In pediatric dilated cardiomyopathy, conventional treatment is associated with recovery of systolic function in approximately 41% of patients, and neither age nor initial ejection fraction significantly differentiate favorable outcomes.
Answers are grounded in this paper and cite their sources.
Initial EF does not predict recovery or death in pediatric DCM on conventional therapy; leaves open identification of reliable prognostic markers.
The purpose of this study was to review our experience with conventional treated pediatric dilated caridomyopathy patients in our region and attempt to discover prognostic factors. We analyzed retrospectively the outcome of 41 patients during last six years. The patients were 23 girls, and 18 boys, ejection fraction 31.6±7.8%, follow-up period 14.07±14.2 months. Eight patients (19.5%) had died, 17 (41.4%) had recovery of systolic function. When analyzed from regained normal systolic function (17 patients) and others, first ejection fraction was not statistically significant (p=0.743). When separated from patient presentation age, 58.5% were smaller than two years. Sixth patients (25%) were died in smaller and two (11.7%) in bigger. Comparison between groups were not statistically differences (p=0.632 for deaths, p=0.594 for ejection fraction). We concluded that age; degrees of systolic functions were not differentiated favorable outcomes.
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Başpınar et al. (2009) conducted an observational in Pediatric Dilated Cardiomyopathy (n=41). Conventional treatment (ACE inhibitors, digitalis, diuretics) was evaluated on Recovery of normal systolic function. In pediatric patients with dilated cardiomyopathy receiving conventional treatment, 41.4% recovered normal systolic function and 19.5% died, with initial ejection fraction not predicting outcomes.
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