What does this research mean for the field?

High extracellular potassium causes the dominant pacemaker site in the sinoatrial region to shift, likely due to true pacemaker cells being more sensitive to potassium than latent pacemaker cells. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

March 1, 1970Circulation ResearchOpen Access

Shifts in Pacemaker Dominance within the Sinoatrial Region of Cat and Rabbit Hearts Resulting from Increase of Extracellular Potassium

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Population

Sinoatrial preparations from cat and rabbit hearts

Design

Preclinical

Authors

HLH. H. LuState University of New York

Discussion

Member takes

Implication

May alter SA node pacemaking in hyperkalemia; extends early observations but leaves open translation to clinical arrhythmias.

Structured PICO

Population

Sinoatrial preparations from cat and rabbit hearts

Intervention

Treatment with high extracellular potassium ([K+])

Outcome

Shift in dominant pacemaker site and changes in action potentials (maximal diastolic potential and slope of prepotential)surrogate

High extracellular potassium shifts the dominant pacemaker site in the sinoatrial node due to differential sensitivity between true and latent pacemaker cells.

Cite This Study

H. H. Lu (1970) studied this question.

synapsesocial.com/papers/6a156b459b87f33fc69f8a2a https://doi.org/10.1161/01.res.26.3.339

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Shifts in Pacemaker Dominance within the Sinoatrial Region of Cat and Rabbit Hearts Resulting from Increase of Extracellular Potassium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Shifts in Pacemaker Dominance within the Sinoatrial Region of Cat and Rabbit Hearts Resulting from Increase of Extracellular Potassium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider