Key result
A 1 SD decline in central serotonergic responsivity was associated with increased odds of metabolic syndrome (OR 2.05; 95% CI 1.10-3.83; P=0.002).
Why the study?
Is low central nervous system serotonergic responsivity associated with the metabolic syndrome and physical inactivity in adult volunteers?
Cross-Sectional (n=270)
Is low central nervous system serotonergic responsivity associated with the metabolic syndrome and physical inactivity in adult volunteers?
Effect estimate: OR 2.05 (95% CI 1.10-3.83)
p-value: p=0.002
Reduced central nervous system serotonergic responsivity is significantly associated with an increased likelihood of having the metabolic syndrome and its individual risk components.
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Hypothesis-generating for serotonergic pathways in metabolic syndrome; prospective studies needed before clinical consideration.
Muldoon et al. (2004) conducted a cross-sectional in Metabolic syndrome (n=270). Central nervous system serotonergic responsivity (prolactin response to fenfluramine) was evaluated on Metabolic syndrome (NCEP definition) (OR 2.05, 95% CI 1.10-3.83, p=0.002). A 1 SD decline in central serotonergic responsivity was associated with increased odds of metabolic syndrome (OR 2.05; 95% CI 1.10-3.83; P=0.002).
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