Key result
Segmental pulmonary vein isolation led to de novo PV narrowing in 26% of PVs and asymmetric diameter reduction (14% supero-inferior vs 9% antero-posterior; P<0.0001).
Why the study?
Does segmental pulmonary vein isolation alter pulmonary vein morphology in patients with atrial fibrillation?
Observational (n=30)
Does segmental pulmonary vein isolation alter pulmonary vein morphology in patients with atrial fibrillation?
Segmental pulmonary vein isolation causes asymmetric luminal reduction and longitudinal shrinkage of the PV trunk, highlighting the need for multi-directional imaging assessment post-ablation.
Supports multiplanar CT surveillance after segmental PVI; leaves open effects on long-term patency or AF outcomes.
BACKGROUND: The morphology of the pulmonary veins (PVs) before and after segmental isolation of the PVs has not been sufficiently characterized. METHODS AND RESULTS: Multi-slice computed tomography was performed before and 3 +/- 1 months after ablation in 30 patients with atrial fibrillation who underwent PV isolation. Before ablation, PV narrowing (> or =25% luminal reduction) was found in nine (8%) PVs. After ablation, de novo PV narrowing was found in 24 PVs (26%) and was detected only in the supero-inferior direction in 14 PVs (58%). The diameter reduction inside the PVs after ablation was greater in the supero-inferior direction (14 +/- 12%) than in the antero-posterior direction (9 +/- 13%; P < 0.0001). In the ablated PVs, the PV trunk was shorter than before ablation (P < 0.0001). The reduction in the diameters of both the PV ostium and the ablation site in the ablated PVs, as well as the diameter of the PV ostium in the nonablated PVs, correlated with the decrease in the left atrial diameter. Shortening of the PV trunk correlated with the severity of PV narrowing, but it was not related to the percent diameter reduction of the left atrium. PV narrowing before or after ablation did not result in any clinical consequences. CONCLUSIONS: PV narrowing is present in about 10% of PVs before ablation. Asymmetric luminal reduction and longitudinal shrinkage of the PV trunk occur after ablation. Reverse remodeling of the PV and contraction of the PV wall may contribute to the reduction in the PV diameter. PV morphology should be assessed with multi-directional views to avoid missing heterogeneous legions.
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Ueda et al. (2005) conducted an observational in Atrial fibrillation (n=30). Segmental isolation of the pulmonary veins vs. Before ablation was evaluated on Diameter reduction inside the PVs after ablation (supero-inferior vs antero-posterior direction) (p=<0.0001). Segmental pulmonary vein isolation led to de novo PV narrowing in 26% of PVs and asymmetric diameter reduction (14% supero-inferior vs 9% antero-posterior; P<0.0001).
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