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August 1, 1959American Journal of Physiology-Legacy Content

Myocardial metabolic and electrical properties of rabbits and ground squirrels at low temperatures

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Population

Rabbit and arctic ground squirrel hearts and ventricular tissue

Comparison

Exposure to low temperatures vs Normal temperatures (35°-38°C)

Design

Preclinical

Authors

BCBenjamín G. CovinoBoston CollegeJHJohn P. HannonU.S. Army Research Institute of Environmental Medicine

Discussion

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Implication

Hibernator cardiac tolerance to deep hypothermia may inspire protective strategies; leaves open translation to human therapeutic hypothermia.

Structured PICO

P
Population
Rabbit and arctic ground squirrel hearts and ventricular tissue
I
Intervention
Exposure to low temperatures (in vitro perfusion cooling below 25°C and in vivo cooling to 15°C rectal temperature)
C
Comparator
Normal temperatures (35°-38°C)
O
Outcome
Myocardial metabolic and electrical properties (contraction rates, diastolic ventricular excitability, coronary flow rates, ATP levels, and oxidase activity)surrogate

Arctic ground squirrels exhibit greater myocardial metabolic and electrical tolerance to hypothermia compared to rabbits, maintaining ATP levels and excitability at low temperatures.

Cite This Study

Covino et al. (1959) studied this question.

synapsesocial.com/papers/6a156fd99b87f33fc69f8e05https://doi.org/10.1152/ajplegacy.1959.197.2.494
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential Effects of Acetylcholine on Coronary Flow in Isolated Hypothermic Hearts From Rats and Ground Squirrels1993 · 11 citations
  2. 2Ca2+ uptake by cardiac sarcoplasmic reticulum at low temperature in rat and ground squirrel1997 · 42 citations
  3. 3Interaction of Heart Rate and Hypothermia on Global Myocardial Contraction of the Isolated Rabbit Heart1996 · 32 citations
  4. 4Interaction of Heart Rate and Hypothermia on Global Myocardial Contraction of the Isolated Rabbit Heart1996 · 11 citations
  5. 5Effects of hypothermia on energy metabolism in rat and Richardson’s ground squirrel hearts1997 · 16 citations