Key result
Colour M-mode tissue Doppler imaging showed cats with hypertrophic cardiomyopathy had lower peak early diastolic myocardial velocity gradients (E1) than normal cats (5.71 vs 11.38 sec-1; P<0.001).
Why the study?
Does colour M-mode tissue Doppler imaging detect differences in myocardial velocity gradients between healthy cats and cats with hypertrophic cardiomyopathy?
Case-Control (n=37)
Does colour M-mode tissue Doppler imaging detect differences in myocardial velocity gradients between healthy cats and cats with hypertrophic cardiomyopathy?
Absolute Event Rate: 5.71% vs 11.38%
p-value: p=<0.001
Colour M-mode tissue Doppler imaging demonstrates decreased myocardial velocity gradients during diastole and systole in cats with hypertrophic cardiomyopathy, allowing discrimination from healthy myocardium.
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May enable noninvasive diastolic assessment in feline HCM models; leaves open prospective clinical validation.
Koffas et al. (2008) conducted a case-control in Hypertrophic cardiomyopathy (n=37). Colour M-mode tissue Doppler imaging vs. Normal cats was evaluated on Peak myocardial velocity gradient during the first phase (E1) of early diastole (p=<0.001). Colour M-mode tissue Doppler imaging showed cats with hypertrophic cardiomyopathy had lower peak early diastolic myocardial velocity gradients (E1) than normal cats (5.71 vs 11.38 sec-1; P<0.001).
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