During a period of one hour's moderate exercise, walking on a treadmill, in the post‐absorptive state, the mean concentration of non‐esterified fatty acids (NEFA) in ten healthy subjects rose from 0–76 to 1–44 m‐mole/ l. This observation is consistent with the view that fat is transported as NEFA from adiposetissue to muscle, as a fuel for exercise. In two patients with hypopituitarism and in three patients after adrenalectomy, plasma NEFA concentration rose in a similar manner on exercise. Possible physiological factors, which may regulate the mobilization of NEFA, are discussed. We wish to acknowledge the help of Mr. David Shirling with these experiments.
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Basu et al. (1960) studied this question.