A simple method for the preparation of a highly stable and reliable surface-enhanced Raman scattering (SERS) substrate was proposed. The SERS enhancement was demonstrated with good controllability and reproducibility through the controlled formation/deformation of SERS "hotspots" using a reversible DNA nanoswitch. Highly effective DNA detection was achieved using a well-designed sandwich structure.
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Wen et al. (2012) studied this question.
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