Key result
Selection of endpoints in atrial fibrillation studies lacks consensus, highlighting the urgent need for carefully crafted composite clinical endpoints rather than poorly correlated surrogate measures.
Population
Patients with atrial fibrillation
Design
Review
Authors
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Inconsistent AF endpoints limit trial interpretability; supports consensus on standardized composites for future studies.
The review highlights the urgent need for consensus on clinically relevant endpoints, such as carefully crafted composite clinical endpoints, in atrial fibrillation rhythm management studies.
D. George Wyse (2002) conducted a review in Atrial fibrillation. Selection of endpoints in atrial fibrillation studies lacks consensus, highlighting the urgent need for carefully crafted composite clinical endpoints rather than poorly correlated surrogate measures.