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October 1, 1969Circulation Research198 citations

Mechanism of Action of Epinephrine and Glucagon on the Canine Heart: EVIDENCE FOR INCREASE IN SARCOTUBULAR CALCIUM STORES MEDIATED BY CYCLIC 3',5'-AMP

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Population

Microsomal fraction of canine myocardium (representing sarcoplasmic reticulum)

Design

Preclinical

Authors

MEMark L. EntmanHeart Failure & TransplantGLGerald S. LeveySprint (United States)SEStephen E. EpsteinBroad Institute

Discussion

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Overview

Distinguishes beta-adrenergic from glucagon pathways in cardiac calcium handling; hypothesis-generating for inotropic mechanisms in humans.

Structured PICO

P
Population
Microsomal fraction of canine myocardium (representing sarcoplasmic reticulum)
I
Intervention
Cyclic 3',5'-AMP, epinephrine, and glucagon
O
Outcome
Calcium accumulation and adenyl cyclase activitysurrogate

The positive inotropic effects of epinephrine and glucagon are likely mediated by an elevation of cyclic 3',5'-AMP levels, which augments the sarcotubular calcium pool.

Cite This Study

Entman et al. (1969) studied this question.

synapsesocial.com/papers/6a1595b2cb0379474a825bcahttps://doi.org/10.1161/01.res.25.4.429
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