Key result
Adding atrial fibrillation to the Wells criteria significantly increased the sensitivity for diagnosing pulmonary embolism compared to the standard Wells score (89.7% vs 61.8%, p<0.001).
Why the study?
Atrial fibrillation is a known risk factor for pulmonary embolism, but whether incorporating it into the Wells criteria improves the diagnosis of pulmonary embolism has not been evaluated.
Does adding atrial fibrillation to the Wells criteria improve the diagnostic sensitivity for pulmonary embolism in patients presenting to the emergency department?
Observational (n=250)
Does adding atrial fibrillation to the Wells criteria improve the diagnostic sensitivity for pulmonary embolism in patients presenting to the emergency department?
Adding atrial fibrillation to the Wells criteria significantly improves its sensitivity for diagnosing pulmonary embolism in emergency department patients.
Answers are grounded in this paper and cite their sources.
May enhance PE detection in ED patients with AF; hypothesis-generating and requires prospective validation before practice change.
Among the various clinical scoring methods used for the prediagnosis of pulmonary embolism (PE), Wells criteria is the most common. It relies on the findings and story of deep venous thrombosis (DVT), PE and malignancy. It is known that atrial fibrillation (AF) is a risk factor for PE like as DVT or malignancy. We aimed to evaluate the possibility of diagnosing more patients with PE by including AF in the Wells criteria. This prospective study included 250 patients admitted to the emergency department with PE findings. Wells scoring and Wells scoring with AF were performed for each patient. Out of 250 patients, 165 patients were diagnosed as PE. Wells score was >4 in 61.8% of patients with PE and 28.2% of patients without PE. Out of false negative 63 patients with PE, 21 of them had AF. According to Wells scoring with AF the score of 148 (89.7%) patients with PE diagnosis was ≥3, whereas the score of 45 (52.9%) patients without PE was ≥3. AF was detected in 15.8% of patients with PE. The sensitivity of Wells score with AF was significantly higher than that of the Wells score (p<0.001). As a result, when AF, which is one of an important PE cause such as DVT and malignancy, was added to the Wells criteria, an additional correct PE estimate was obtained in 46 patients. We recommend using Wells score with AF since prediagnosing more PE is more valuable than having some false negative PE predictions.
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Hasanoğlu et al. (2019) conducted an observational in Pulmonary embolism (n=250). Wells scoring with atrial fibrillation vs. Standard Wells scoring was evaluated on Sensitivity for diagnosing pulmonary embolism (p=<0.001). Adding atrial fibrillation to the Wells criteria significantly increased the sensitivity for diagnosing pulmonary embolism compared to the standard Wells score (89.7% vs 61.8%, p<0.001).
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