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Aim: To assess thyrotropin (thyroid-stimulating hormone; TSH) suppression and serum thyroxine (T4) concentrations in infants with congenital hypothyroidism in relation to T4 dose and pretreatment parameters. Method: A retrospective study of all cases treated in a single centre since neonatal screening began was performed. Results: In 54 infants treated with a mean daily T4 dose of 9.8 µg/kg, the TSH concentration was suppressed (4 level at the upper end of the infant reference range. Infants who suppressed their TSH later did not differ in pretreatment serum TSH or T4 concentration. T4 dose and serum T4 level were lower in infants whose TSH was not suppressed. Conclusions: TSH suppression in congenital hypothyroidism is significantly related to serum levels and dosage of T4. We suggest that a delay in TSH suppression is mainly due to undertreatment.
Brown et al. (Wed,) studied this question.