Amplification of Dynamic Chiral Crown Ether Complexes During Cyclic Acetal Formation

The dynamic duo: A more than tenfold increase in the yield of the chiral macropolycyclic polyether containing two 2,6-disubstituted 1,3,5,7-cis-tetraoxadecalin systems was obtained under thermodynamic conditions from a dynamic combinatorial virtual library with templating cesium ions (>95 % yield, see schematic representation) relative to kinetic syntheses (<8 % yields in their macropolycyclization steps), even when the same template was used. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z51558_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.