Addressable DNA arrays are created by photopatterning self-assembled monolayers to form hydrophilic and hydrophobic regions on a gold surface. The hydrophilic regions aid to contain small volumes of different DNA solutions placed on them using an automated pin-tool loading strategy. The method allows for efficient attachment, manipulation, and hybridization of pure DNA strands on the surface.
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Gillmor et al. (2000) studied this question.
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