Endothelin System in Human Persistent and Paroxysmal Atrial Fibrillation
Key result
Atrial fibrillation, particularly with underlying valve disease, was associated with significant alterations in endothelin system expression, including a 40% increase in pro-ET-1 mRNA (P=0.002).
Why the study?
Are mRNA and protein expression levels of the endothelin system altered in the right atrial appendages of patients with atrial fibrillation compared to those in sinus rhythm?
Population
72 patients, comprising 36 with paroxysmal or persistent atrial fibrillation and 36 controls in sinus rhythm.
Design
Case-control
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for endothelin modulation in valvular AF; leaves open causal role and clinical benefit.
Study Design
Type
Case-Control (n=72)
Structured PICO
Are mRNA and protein expression levels of the endothelin system altered in the right atrial appendages of patients with atrial fibrillation compared to those in sinus rhythm?
P
Population
72 patients, comprising 36 with paroxysmal or persistent atrial fibrillation (with or without underlying valve disease) and 36 controls in sinus rhythm.
C
Comparator
36 controls in sinus rhythm
O
Outcome
mRNA and protein expression levels of pro-endothelin-1 (pro-ET-1), endothelin receptor A (ET-A), and endothelin receptor B (ET-B) in right atrial appendagessurrogate
The endothelin system undergoes significant gene and protein expression changes in the human atria during atrial fibrillation, particularly when associated with underlying valve disease.
Cite This Study
BRUNDEL et al. (2001) conducted a case-control in Atrial Fibrillation (n=72). Atrial fibrillation vs. Sinus rhythm was evaluated on mRNA and protein expression levels of the endothelin system (pro-ET-1, ET-A, and ET-B). Atrial fibrillation, particularly with underlying valve disease, was associated with significant alterations in endothelin system expression, including a 40% increase in pro-ET-1 mRNA (P=0.002).