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July 1, 1969Cardiovascular Research

Protective Influence of Cardiac Denervation Against Arrhythmias of Myocardial Infarction

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Why the study?

Does total cardiac denervation prevent arrhythmias following coronary occlusion in dogs?

Population

10 normal awake dogs

Comparison

Total cardiac denervation prior to coronary… vs Normal state prior to coronary occlusion

Design

Preclinical

Authors

SSStephen F. SchaalThe Ohio State University Wexner Medical CenterAWAndrew G. WallaceUniversity of GreenwichWSWill C. SealyElectrophysiology

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Implication

May reduce post-occlusion arrhythmias via denervation in dogs; leaves open translation to human ventricular arrhythmia prevention.

Key Points

  • The aim is to evaluate the effect of cardiac denervation on arrhythmias induced by myocardial infarction.
  • Conducted experiments on 10 awake dogs
  • Induced coronary occlusion to assess arrhythmia prevalence
  • Tested effects before and after total cardiac denervation
  • All dogs exhibited frequent premature beats and ventricular tachycardia during coronary occlusion before denervation.
  • Post-denervation, only 2 out of 10 dogs developed arrhythmias after coronary occlusion.

Structured PICO

Does total cardiac denervation prevent arrhythmias following coronary occlusion in dogs?

P
Population
10 normal awake dogs
I
Intervention
Total cardiac denervation prior to coronary occlusion
C
Comparator
Normal state (intact innervation) prior to coronary occlusion
O
Outcome
Incidence of arrhythmias (premature beats and ventricular tachycardia) following coronary occlusionsurrogate

Total cardiac denervation significantly reduces the incidence of arrhythmias following coronary occlusion in a canine model.

Cite This Study

Schaal et al. (1969) studied this question.

synapsesocial.com/papers/6a15c1c8a2352da34782df46https://doi.org/10.1093/cvr/3.3.241
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adverse effects of chronic cardiac denervation in conscious dogs with myocardial ischemia.1985 · 41 citations
  2. 2Effect of chronic cardiac denervation on arrhythmias after coronary artery ligation1970 · 114 citations
  3. 3Responses to coronary artery occlusion in conscious dogs with selective cardiac denervation1988 · 15 citations
  4. 4Coronary Circulation in the Conscious Dog with Cardiac Neural Ablation1972 · 63 citations
  5. 5Cardiac Rhythm Disturbances and the Release of Catecholamines After Acute Coronary Occlusion in Dogs1969 · 126 citations