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Scholarship on the global history of psychedelics is divided into two rival approaches. This article analyzes these approaches, emphasizing the way in which ideological biases on both sides have stymied serious research on the use of psychedelic substances across space and time, before introducing the empirical approach as an alternative. The most prevalent view, “pharmacological Calvinism,” essentializes mind-altering drugs and their users as degenerate or antisocial. This reductive approach has defined the intellectual mainstream across academic disciplines to the present. In contrast to pharmacological Calvinism, the entheogenic school offers a maximalist interpretation of psychedelics’ impact on human culture and cognition, presenting consciousness-expanding drugs as the “secret key” behind the world's religious traditions, mythology, and folklore. This article proposes that the empirical approach offers a corrective to the overstatements of both schools, as it is defined by comparatively granular research that draws from a deep understanding of primary sources placed in conversation with the intellectual apparatuses of the secondary literature. Distinctly uninterested in unveiling psychedelics as the “key” to any tradition, this approach interprets the multiplicity of meanings and values associated with powerful psychotropics, alongside other modes of ecstasy and transpersonal relationality, as an integral dimension of the human story.
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Joseph Christian Greer (2025) studied this question.
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