Key result
In rat ventricular trabeculae, the magnitude of sarcomere length-dependent changes in maximum Ca2+-activated force was significantly smaller in those expressing the giant N2BA-G titin isoform compared to the wild-type N2B isoform.
Population
Skinned right ventricular trabeculae isolated from wild-type and mutant homozygote rats expressing…
Comparison
Stretching trabeculae from sarcomere length 2.0… vs Wild-type trabeculae expressing predominantly…
Design
Preclinical
Authors
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Titin isoform effects on length-dependent force remain hypothesis-generating in rodents; leaves open translation to human HF.
Absolute Event Rate: 5.85% vs 9.3%
p-value: p=<0.05
The magnitude of sarcomere length-dependent changes in passive force, maximum Ca2+-activated force, Ca2+ sensitivity, and cooperativity in rat ventricles is defined by the titin isoform.
Patel et al. (2011) studied Titin isoform expression in rat ventricles (n=17). Giant N2BA-G titin isoform (Homozygote) vs. Smaller N2B titin isoform (Wild-type) was evaluated on Magnitude of sarcomere length-dependent changes in maximum Ca2+-activated force (mN/mm2) (p=<0.05). In rat ventricular trabeculae, the magnitude of sarcomere length-dependent changes in maximum Ca2+-activated force was significantly smaller in those expressing the giant N2BA-G titin isoform compared to the wild-type N2B isoform.
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