Key result
Twelve weeks of aerobic training slightly increases resting cTnT vs control, independent of LV mass.
Why the study?
It was unknown whether exercise training mediates cardiac troponin T (cTnT) and whether this is associated with increases in left ventricular mass (LVM).
Does 12 weeks of high-intensity interval training or continuous aerobic training increase resting serum cardiac troponin T and left ventricular mass in sedentary obese women?
RCT (n=54)
Does 12 weeks of high-intensity interval training or continuous aerobic training increase resting serum cardiac troponin T and left ventricular mass in sedentary obese women?
Absolute Event Rate: 3.76% vs 3.45%
p-value: p=<0.05
Twelve weeks of exercise training (HIIT or CAT) increases resting high-sensitivity cardiac troponin T in sedentary obese women, independent of changes in left ventricular mass.
May warrant accounting for recent training when interpreting resting hs-cTnT; extends evidence that troponin rises occur independently of LV mass.
The purpose of this study was to determine whether exercise training mediated cardiac troponin T (cTnT) and whether this was associated with increases in left ventricular mass (LVM). Fifty-four sedentary obese women were randomised to high-intensity interval training (HIIT, repeated 4–min cycling at 90% V̇O2max interspersed with 3–min rest), work-equivalent continuous aerobic training (CAT, continuous cycling at 60% V̇O2max) or a control group (CON). Resting serum cTnT was assessed using a high-sensitivity assay before and after 12 weeks of training. LVM was determined from 2D echocardiography at the same timepoints. Both HIIT and CAT induced a similar elevation (median 3.07 to 3.76 ng.l−1, p<0.05) in resting cTnT compared with pre-training and the CON (3.49 to 3.45 ng.l−1, p>0.05). LVM index in HIIT increased (62.2±7.8 to 73.1±14.1 g.m−2, p<0.05), but not in CAT (66.1±9.7 to 67.6±9.6 g.m−2, p>0.05) and CON (67.9±9.5 to 70.2±9.1 g.m−2, p>0.05). Training-induced changes in resting cTnT did not correlate with changes in LVM index (r=−0.025, p=0.857). These findings suggest that twelve weeks of either HIIT or CAT increased resting cTnT, but the effects were independent of any changes in LVM in sedentary obese women.
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Kong et al. (2021) conducted an RCT in Obesity (n=54). High-intensity interval training (HIIT) or continuous aerobic training (CAT) vs. Control group was evaluated on Resting serum cardiac troponin T (cTnT) (p=<0.05). Twelve weeks of either high-intensity interval or continuous aerobic training increased resting cTnT compared to control (median 3.76 vs 3.45 ng/L; p<0.05), independent of left ventricular mass.
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