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The enzymatic synthesis of the polyribonucleotide by the use of RNA polymerase is described. Snake venom and spleen phosphodiesterase degrade this polymer at a very slow rate compared to poly r(A—U). The dinucleotide resulting from digestion with pancreatic ribonuclease is resistant to spleen phosphodiesterase.
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Matzura et al. (1968) studied this question.
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