Key result
High daily salt intake is linked to ~8-fold higher odds of numerous coronary segmental lesions.
Why the study?
Excess sodium intake increases the risk of IHD, and the study aimed to determine salt intake in CABG patients and evaluate its relationship with atheroma development.
Does high salt intake increase the risk of atheroma development (segmental lesions) in patients with ischaemic heart disease?
Cross-Sectional (n=233)
No
Does high salt intake increase the risk of atheroma development (segmental lesions) in patients with ischaemic heart disease?
Effect estimate: OR 8.54 (95% CI 4.545-16.734)
p-value: p=<0.01
High daily sodium intake is strongly associated with increased atheroma formation in coronary segments among patients with ischaemic heart disease, reinforcing the importance of dietary sodium restriction.
High salt intake was associated with more coronary lesions in IHD; hypothesis-generating and should not yet change practice.
Background: Sodium assists in maintaining body fluid balance. Excess sodium intake increases the risk of ischaemic heart disease (IHD) adding to global and local mortality due to non-communicable diseases. Aim: To determine the salt intake levels of patients having coronary artery bypass grafting (CABG) and to explain the relationship between salt consumption and atheroma development. This study used an adapted cross-sectional design with 233 patients admitted to Sri Jayewardenepura General Hospital with acute heart diseases. Method: Demographic and lifestyle-related data, medical history and food intake data were collected. Salt intake was calculated based on the consumption of salt used per month at household level, salt added to food – including in restaurants. Salt content was determined using web-based applications and food tables. Multivariate logistic regression was used to identify variables significantly associated with IHD. Results: In this study, the daily intake of sodium per person was 6,176 mg. This was much higher than WHO’s recommended level of 2,000 mg/day, demonstrating a significant relationship between segmental lesions and sodium intake (p<0.01). The multivariate binary logistic model demonstrated that high salt intake (OR 8.54; 95% CI [4.545–16.734]) and the presence of diabetes (OR 2.23; 95% CI [1.206–4.238]), contributed to the high number of segmental lesions (p<0.01). Conclusion: A high daily intake of sodium increases the risk of atheroma formation in more coronary segments, regardless of age, sex, several known disease conditions and risk factors.
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Amadoru et al. (2023) conducted a cross-sectional in Ischaemic heart disease (n=233). High salt intake was evaluated on High number of segmental lesions (OR 8.54, 95% CI 4.545-16.734, p=<0.01). High daily salt intake was significantly associated with a higher number of coronary segmental lesions (OR 8.54; 95% CI 4.545-16.734; p<0.01).
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