Infectious diseases, cardio-cerebrovascular health and vaccines: pathways to prevention

Cardiovascular and infectious diseases both feature among the leading causes of death among men and women in the world. The pathophysiological pathways of infection and cardiovascular disease intersect, and there is a bidirectional relationship between the two. Vaccines are available for the most common infectious diseases affecting older adults, such as influenza, pertussis, pneumococcal disease, herpes zoster, COVID and respiratory syncytial virus (RSV). In many countries, these vaccines are recommended systematically for older adults and any adults with comorbidities, who are also those most likely to suffer from cardiovascular disease. There is a large body of evidence attesting to the benefits of vaccination on cardio- and cerebrovascular health. The European Interdisciplinary Council for Aging (EICA) and the Italian Society for Cardiovascular Prevention (Società Italiana per la Prevenzione Cardiovascolare, SIPREC) convened a 2-day meeting in June 2024 to review the state of the evidence on the relationship between cardio- and cerebrovascular health and the most common infectious diseases, and the role of vaccines in preventing both infection and its adverse consequences in terms of cardiovascular and cerebrovascular outcomes. We present here the Executive Summary of the proceedings of this meeting.