Key result
Prophylactic LMWH linked to ~45% higher blood product use during geriatric vertebral surgery versus no prophylaxis.
Why the study?
The widespread use of antiaggregants and anticoagulants in elderly patients increases bleeding risks during vertebral surgery, making effective preoperative evaluation and bleeding management crucial.
Does the use of antiaggregants or prophylactic LMWH increase perioperative bleeding in geriatric patients undergoing vertebral surgery?
Cohort (n=80)
No
Does the use of antiaggregants or prophylactic LMWH increase perioperative bleeding in geriatric patients undergoing vertebral surgery?
Absolute Event Rate: 74.5% vs 51.5%
p-value: p=0.034
Discontinuing antiaggregants and oral anticoagulants 7 days prior to vertebral surgery in geriatric patients does not significantly increase perioperative bleeding, though prophylactic LMWH increases intraoperative blood product utilization.
LMWH prophylaxis was associated with higher transfusion rates; leaves open optimal VTE strategy in geriatric vertebral surgery.
Background: The world is witnessing an increase in its elderly population, which is reflected in the growing number of orthopedic surgeries being performed. With the increase in the number of major operations performed on the elderly, it has become crucial to manage bleeding effectively during vertebral surgery. The substantial use of antiaggregants and anticoagulants in elderly patients presents an increased risk of bleeding, resulting in increased morbidity and mortality rates if not well managed. Hence, it is essential to evaluate these patients thoroughly in the pre-operative period to minimize the risk of bleeding and improve patient outcomes. Aims and Objectives: The aims of this study were to research how effective the use of antiaggregants (AAs) and anticoagulants (oral anticoagulants [OAC] and low-molecular-weight heparin [LMWH]) is on operations and post-operative bleedings in surgery performed at our orthopedics clinic especially in the geriatric age group. Materials and Methods: This study was made retrospectively on 80 patients aged 65 years and over, who have undergone vertebral surgery on hospitalization at the Istanbul Florence Nightingale Hospital’s Orthopedics Clinic between the months of January 2017 and December 2019. Results: The rate of blood product utilization during surgery of those using prophylactic LMWH was statistically significantly higher in comparison to those not on prophylactic LMWH (P=0.034). There has not been determined any statistically significant difference in the means of the bleeding amount during the operation and post-operative bleeding. There has not been determined any statistically significant difference in the means of the bleeding amount during the operation and the post-operative period use and do not use any AA. Conclusion: In the geriatric group of age, which shall undergo vertebral surgery, it seems like an appropriate approach to discontinue AA and OAC 7 days before the operations. We have observed that the utilization of LMWH either for prophylactic purposes or for bridging purposes in the group using OAC does not significantly increase the bleeding probability.
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Yardımcı et al. (2023) conducted a cohort in Geriatric patients undergoing vertebral surgery (n=80). Prophylactic low-molecular-weight heparin (LMWH) vs. No prophylactic LMWH was evaluated on Blood product utilization during operation (p=0.034). Prophylactic use of low-molecular-weight heparin significantly increased the rate of blood product utilization during vertebral surgery in geriatric patients compared to no prophylaxis (74.5% vs 51.5%, P=0.034).
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