Key result
Computational transmural wedge models highlight the need to investigate conductivity tensors for accurate organ-level ECGs.
Why the study?
Numerical simulations of the human heart can guide clinicians and researchers only if properly validated.
This computational framework provides a method to validate cardiac electrophysiology models at the tissue level, emphasizing the critical role of the conductivity tensor in accurately simulating ECG morphology.
No immediate clinical modeling changes; leaves open conductivity tensor refinement for accurate organ-level ECG simulation.
Numerical simulations of the human heart can guide medical doctors and researchers only if properly validated. This work presents a computational framework to validate mathematical models of cardiac electrophysiology at the tissue level. Specifically, we focus on the transmural wedge experiment as proposed by Antzelevitch in 1996. This experimental setup is easily reproduced and allows to probe key modeling assumptions and components before organ level simulations are performed. Our results highlight the need to further investigate the conductivity tensor, which, by modifying wave propagation, will affect the ECG morphology at the organ level.
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Ogiermann et al. (2021) studied Cardiac electrophysiology. Computational framework for transmural wedge experiment was evaluated on Validation of mathematical models of cardiac electrophysiology. A computational framework for the transmural wedge experiment highlights the need to further investigate the conductivity tensor to accurately model ECG morphology at the organ level.
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