Key result
Shox2 regulates dorsal mesenchymal protrusion fate and development by controlling BMP signaling through the Smad-dependent pathway to drive tissue growth and induce Hcn4 expression.
The Shox2-BMP pathway is critical for the development of the dorsal mesenchymal protrusion and its temporary pacemaker function during early heart development.
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Draft 3:* Holds no immediate clinical application for arrhythmia management;.
Sun et al. (2014) studied Dorsal mesenchymal protrusion development during cardiogenesis. Shox2 deletion / Bmp4 deletion or inhibition vs. Wild-type / Control mice was evaluated on DMP development and Hcn4 expression. Shox2 regulates dorsal mesenchymal protrusion fate and development by controlling BMP signaling through the Smad-dependent pathway to drive tissue growth and induce Hcn4 expression.
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