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ABSTRACT Hepatocellular carcinoma (HCC) therapy has evolved rapidly with the introduction of immune checkpoint inhibitors and targeted anti‑angiogenic agents. Randomized clinical trials remain the cornerstone for evaluating treatment efficacy, yet interpretation of their results requires careful consideration of endpoint selection, survival analysis methodology, and the clinical complexity of patients with cirrhosis. Overall survival remains the most robust endpoint in oncology trials, although surrogate endpoints such as progression‑free survival, time‑to‑progression, and objective response rate are frequently used to accelerate drug development. The validity of surrogate endpoints in hepatocellular carcinoma remains debated due to tumor heterogeneity, competing risks related to liver disease, and the influence of post‑progression therapies. Furthermore, immunotherapy has introduced challenges to traditional statistical models through delayed treatment effects and violations of the proportional hazard assumption. This narrative review summarizes methodological principles required to interpret systemic therapy trials in HCC and discusses their implications for clinical practice.
Piñero et al. (2026) studied this question.