Why the study?
Do plasma insulin and blood sugar responses to an oral glucose tolerance test differ in men with atherosclerotic peripheral vascular disease compared to healthy controls?
Do plasma insulin and blood sugar responses to an oral glucose tolerance test differ in men with atherosclerotic peripheral vascular disease compared to healthy controls?
Men with atherosclerotic peripheral vascular disease exhibit an exaggerated plasma insulin response to oral glucose, suggesting hyperinsulinemia may play a role in the etiology of atherosclerosis.
Hyperinsulinemia may contribute to atherosclerosis; level 4 evidence leaves open causality and precludes practice change.
Oral glucose tolerance tests were carried out on 51 men with atherosclerotic peripheral vascular disease, none of whom were known diabetics or had suffered recent myocardial infarction. The plasma insulin and blood sugar responses were compared with 47 age and sex-matched controls. There was no significant difference in obesity between the two groups. The patient group showed an increased plasma insulin response with a delay in return to fasting levels, and the blood sugar response was similar. These results suggest that hyperinsulinaemia and hyperglycaemia are often associated with atherosclerosis, and may have a role in its aetiology.
No takes yet. Share an insight, caveat, or question.
Sloan et al. (1970) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: