Key result
Sinus rhythm restoration via electrical cardioversion rapidly improved left ventricular ejection fraction from 30% at baseline to 53% at 40 days (P<0.001) in patients with HFrEF and AF.
Why the study?
The time course and potential predictors of response to sinus rhythm restoration in patients with atrial fibrillation and heart failure were uncertain.
Does electrical cardioversion for sinus rhythm restoration improve left ventricular ejection fraction in patients with non-ischaemic heart failure and concomitant atrial fibrillation?
Population
50 consecutive patients with heart failure, reduced EF, and concomitant AF
Comparison
Sinus rhythm restoration via electrical cardioversion
Design
Prospective cohort study
Follow-up
40 days
Authors
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Supports rapid LVEF gains with sinus rhythm restoration in non-ischaemic HFrEF-AF; hypothesis-generating, requiring randomized confirmation before practice change.
Observational (n=50)
Does electrical cardioversion for sinus rhythm restoration improve left ventricular ejection fraction in patients with non-ischaemic heart failure and concomitant atrial fibrillation?
Absolute Event Rate: 53% vs 30%
p-value: p=<0.001
Sinus rhythm restoration via electrical cardioversion leads to rapid and significant improvement in LVEF in patients with non-ischaemic HFrEF and AF, potentially avoiding the need for primary prevention ICDs.
Müller‐Edenborn et al. (2019) conducted an observational in Heart failure with reduced ejection fraction and atrial fibrillation (n=50). Sinus rhythm restoration via electrical cardioversion vs. Baseline was evaluated on Left ventricular ejection fraction (EF) (p=<0.001). Sinus rhythm restoration via electrical cardioversion rapidly improved left ventricular ejection fraction from 30% at baseline to 53% at 40 days (P<0.001) in patients with HFrEF and AF.
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