Key result
His-Purkinje pacing provides physiological stimulation but requires randomized trials against RVP or BiVP.
His-Purkinje conduction system pacing offers physiological stimulation, but randomized trials comparing it with right ventricular or biventricular pacing are needed before it can become the gold standard.
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His-Purkinje pacing warrants caution before routine adoption; leaves open superiority over right ventricular or biventricular pacing in randomized trials.
His bundle pacing is performed at our centre since 2017 and has been adopted in tertiary centres accross Switzerland. It provides true physiological stimulation, thereby avoiding avoiding the detrimental effects of right ventricular pacing. However, relatively high incidences of lead revision and increases in capture thresholds have been reported. An alternative technique, practiced at our centre since 2020, is left bundle area pacing, which provides excellent electrical parameters. However, long-term data on lead performance and extractibility are lacking. Furthermore, although these techniques are conceptually very attractive, there is a dire need for studies randomizing conduction system pacing with right ventricular / biventricular pacing, before they can be considered as becoming the gold standard.
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Bakelants et al. (2021) conducted a review in Pacing indications. His-Purkinje conduction system pacing (His bundle and left bundle area pacing) vs. Right ventricular / biventricular pacing was evaluated. His-Purkinje conduction system pacing provides physiological stimulation, but randomized trials comparing it to right ventricular or biventricular pacing are needed to establish it as a gold standard.
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