A left anterior descending artery pericoronary fat attenuation index ≥-63.4 HU was significantly associated with an increased risk of hospitalization for HFpEF (HR 4.8) in patients with suspected CAD.
Cohort (n=1,196)
No
Does pericoronary fat attenuation index (FAI) on CCTA predict hospitalization for HFpEF in patients undergoing clinically indicated CCTA?
Pericoronary fat attenuation index on CCTA improves the prediction of hospitalization for HFpEF, suggesting pericoronary inflammation is a useful risk marker.
Effect estimate: HR 4.8 (95% CI 2.1-10.8)
p-value: p=<0.001
BACKGROUND: Pericoronary fat attenuation index (FAI) assessed on computed tomography is associated with the inflammation of the pericoronary artery. OBJECTIVES: This study aimed to investigate whether pericoronary FAI predicts hospitalization for heart failure with preserved ejection fraction (HFpEF). METHODS: This retrospective single-center study included 1,196 consecutive patients who underwent clinically indicated coronary computed tomography angiography (CCTA) and transthoracic echocardiography. We assessed the FAI of proximal 40-mm segments for each major epicardial coronary vessel. The primary outcome was the incidence of hospitalization for HFpEF. Patients were divided into groups based on the optimal cutoff value for predicting hospitalization for HFpEF by receiver operating characteristic curve analysis. RESULTS: , and significant stenosis on CCTA, increased the C-statistic for predicting hospitalization for HFpEF from 0.646 to 0.750 (P = 0.010). CONCLUSIONS: LAD- and left circumflex artery-FAI can predict hospitalization for HFpEF in patients undergoing clinically indicated CCTA. Pericoronary inflammation may be useful for identifying patients at high risk of developing HFpEF.
Nakashima et al. (Fri,) conducted a cohort in Suspected coronary artery disease (n=1,196). High left anterior descending artery fat attenuation index (LAD-FAI ≥-63.4 HU) vs. Low LAD-FAI (<-63.4 HU) was evaluated on Incidence of first hospitalization for heart failure with preserved ejection fraction (HFpEF) (HR 4.8, 95% CI 2.1-10.8, p=<0.001). A left anterior descending artery pericoronary fat attenuation index ≥-63.4 HU was significantly associated with an increased risk of hospitalization for HFpEF (HR 4.8) in patients with suspected CAD.