Key result
CAD is linked to ~3-fold higher UCP1 expression in epicardial adipose tissue versus controls.
Why the study?
To evaluate mRNA and encoded proteins of mitochondrial uncoupling protein genes in epicardial and mediastinal adipose tissues in patients with CAD.
Are the expression levels of UCP1, UCP2, and UCP3 mRNA and proteins in epicardial and mediastinal adipose tissues altered in patients with coronary artery disease compared to controls?
Case-Control (n=166)
Are the expression levels of UCP1, UCP2, and UCP3 mRNA and proteins in epicardial and mediastinal adipose tissues altered in patients with coronary artery disease compared to controls?
Absolute Event Rate: 74.2% vs 24.4%
p-value: p=0.001
Increased expression of UCP1, UCP2, and UCP3 in the epicardial adipose tissue of CAD patients suggests a compensatory protective mechanism against oxidative stress and myocardial damage.
Objective: mRNA and encoded proteins in epicardial and mediastinal adipose tissues in patients with coronary artery disease (CAD). Subjects and methods: mRNA and encoded proteins were measured by quantitative real-time PCR and Western blot analysis, respectively. Results: expression was associated with levels of high-density lipoprotein cholesterol and low-density cholesterol in the epicardial tissue. Conclusion: genes in the epicardial adipose tissue could be a protective mechanism against the production of reactive oxygen species and may guard the myocardium against damage. Thus, UCP levels are essential to maintain the adaptive phase of cardiac injury in the presence of metabolic disorders.
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Huesca‐Gómez et al. (2023) conducted a case-control in Coronary artery disease (n=166). Coronary artery disease vs. Valve replacement surgery (controls) was evaluated on UCP1 mRNA expression in epicardial adipose tissue (median) (p=0.001).
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