Why the study?
Does the combination of S-1 and CPT-11 provide an effective and more convenient alternative to CPT-11 plus infusional 5-FU and LV in patients with advanced colorectal cancer?
Does the combination of S-1 and CPT-11 provide an effective and more convenient alternative to CPT-11 plus infusional 5-FU and LV in patients with advanced colorectal cancer?
The combination of S-1 and CPT-11 is an effective and convenient regimen for advanced colorectal cancer, achieving a 63% response rate and 8-month PFS with manageable toxicity.
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Marinskis et al. (2006) conducted a review in Advanced colorectal cancer. S-1 plus CPT-11 vs. CPT-11 plus infusional 5-FU and LV was evaluated on Response rate.
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