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Full genome sequence comparison of uveitis-causing enterovirus strains excludes the role of recent recombination in their emergence, pointing to their independent emergence.
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Full genome sequence comparison of EU-causing enterovirus strains suggests their independent emergence rather than recent recombination.
The complete nucleotide sequences of three human echovirus (EV) 11 strains and one EV19 strain, all of which caused outbreaks of enterovirus uveitis (EU), a new infant disease first identified in 1980 in Siberia, were determined. One EV11 strain which caused an outbreak of sepsis-like disease in Hungary was also sequenced. All four EV11 strains were mosaic recombinants of the prototype EV11 strain Gregory, with their non-structural coding regions and 5' NTRs being more similar to other prototype enteroviruses (EV1, EV9). However, this finding is probably a feature of all circulating enterovirus strains and may not be related to their altered virulence. A full genome sequence comparison of the three subtypes of EU-causing strains excludes the role of recent recombination in their emergence, and points to their independent emergence.
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Lukashev et al. (2004) studied Enterovirus uveitis. Full genome sequence comparison of uveitis-causing enterovirus strains excludes the role of recent recombination in their emergence, pointing to their independent emergence.
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