Key result
Serum cystatin C levels were significantly correlated with overall mortality in 77-year-old men, with mortality being three times higher in the highest quintile compared to the lowest (p=0.013).
Why the study?
Is increased serum cystatin C associated with increased mortality in elderly men?
Cohort (n=792)
Is increased serum cystatin C associated with increased mortality in elderly men?
p-value: p=0.013
Elevated serum cystatin C is a significant prognostic marker associated with increased overall mortality in elderly men.
Supports cystatin C as mortality marker in elderly men; hypothesis-generating for incremental value over creatinine.
Renal dysfunction measured by serum creatinine is associated with increased cardiovascular morbidity and mortality. Plasma cystatin C has been shown in several studies to be superior to plasma creatinine for the estimation of glomerular filtration rate (GFR). The aim of the present study was to investigate the relationship between cystatin C and mortality in elderly men. Serum cystatin C was analyzed by nephelometry in a group of 77-year-old men (n=792) and correlated cystatin C levels with mortality during a follow-up period of 1-4 years. The cystatin C values were significantly correlated with overall mortality (p=0.013). Mortality was three times higher in the highest cystatin C quintile in relation to the lowest quintile.
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Larsson et al. (2005) conducted a cohort in Elderly men (n=792). Serum cystatin C vs. Lowest cystatin C quintile was evaluated on Overall mortality (p=0.013). Serum cystatin C levels were significantly correlated with overall mortality in 77-year-old men, with mortality being three times higher in the highest quintile compared to the lowest (p=0.013).
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